A unified classification
for the pathologies
of ageing.
The International Consortium to Classify Ageing-Related Pathologies (ICCARP) is a global scientific initiative developing a comprehensive classification and staging framework for ageing-related pathologies, structured for submission to the World Health Organization (WHO) and the International Classification of Diseases (ICD-11).
The problem of unclassified ageing.
Population ageing now constitutes the main structural challenge to global healthcare systems. As populations age, the clinical focus has shifted from acute diseases to chronic conditions, with an emphasis on sustaining the functional capacity and health of individuals. Existing diagnostic frameworks have failed to keep pace with this transition; many ageing-related pathologies remain poorly classified or inconsistently staged. This lack of clinical and pathological resolution limits accurate diagnosis, stratification, and patient management, whilst hindering research coordination, regulatory clarity, epidemiological surveillance, and the development of interventions capable of keeping individuals healthier for longer.
ICCARP is addressing this problem. The consortium was established to directly address taxonomic deficiencies by systematically refining the classification and staging of ageing-related pathologies.
To ensure international clinical utility and scientific consensus, the consortium convenes an international network of over 400 clinical and scientific experts across 29 countries. Operationally, ICCARP executes its mission through 14 specialised working groups, supported by two advisory boards and an executive Steering Committee. The consortium is actively developing a unified, consensus-driven system grounded in current scientific evidence.
The consortium is advancing in four phases:
- i.EvidenceSystematic collation and appraisal of the scientific evidence base
- ii.ClassificationPrecise taxonomic classification of distinct pathologies
- iii.StagingFormulation of standardised clinical staging parameters
- iv.BiomarkersIdentification of validated biomarkers to objectively quantify and monitor pathologies
This framework is systematically applied by each specialist working group within its respective domain, supported by coordinated scientific and policy guidance across the consortium.
These harmonised outputs are structured for submission to the World Health Organization (WHO), providing the formal empirical scaffolding required to facilitate future integration into the International Classification of Diseases (ICD-11) and shape global health policy.

Fourteen specialist working groups. Two advisory boards.
Specialist working groups are coordinated by the Steering Committee and informed by two cross-cutting advisory boards. Each group is led by an international panel of expert clinicians and scientists tasked with refining body-system-level classification. Select a group to filter publications below.
Peer-reviewed consensus & classification.
ICCARP consensus statements, response pieces, and classification proposals are published in GeroScience, Science, The Lancet Healthy Longevity, the European Heart Journal, and other peer-reviewed venues.
Senescence-Related Myocardial Dysfunction: Keeping a Young Heart
doi:10.1093/eurheartj/ehag095Classifying Ageing-Related Pathologies: Submission to the UK Parliament's Science, Innovation & Technology Select Committee
doi:10.6084/m9.figshare.28417670ICCARP Audiovestibular Group: Fostering International Consensus to Refine ICD-11 Codes for Hearing Loss Across the Life Course
doi:10.1007/s11357-025-01742-2Pineal gland senescence: an emerging ageing-related pathology?
doi:10.1007/s42000-025-00720-9Adrenal cortex senescence: an ageing-related pathology?
doi:10.1007/s40618-025-02566-9International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus
doi:10.1007/s11357-025-01509-9Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement
doi:10.1007/s11357-024-01315-9Formal diagnostic criteria are essential for robust clinical trials.
Recognised diagnostic classification and coding are foundational to clinical translation. Without these standards, the design of robust clinical trials, the definition of regulatory endpoints, and the reimbursement of emerging therapies remain substantially constrained. By providing the classification frameworks required for ICD-11 integration, ICCARP aims to support healthcare systems and regulatory bodies in the evaluation and adoption of emerging interventions.

11th Revision (ICD-11)
Founders, coordinators & advisors.
The Steering Committee oversees consortium governance, classification methodology, and submission to international bodies.
Founders


Coordinators


Steering Committee advisors


The international contributors.
Each ICCARP working group is led by an international panel of clinicians and scientists. Filter the directory by group to see contributors in that area. A selection of representative members is shown — the full register is maintained internally.
Working-group members span 29 countries across six continents — hover a marker for the country total.
Select a group below to view its contributors.
Coverage of the case for classifying ageing.
The consortium’s work and the wider scientific case for recognising ageing-related pathologies have been featured in international press and institutional reporting.
Get in touch with the consortium.
For correspondence regarding working-group membership, classification proposals, or institutional partnerships, contact the Steering Committee directly.
ICCARP Steering Committee
Cardiff School of Technologies,
Cardiff Metropolitan University,
Llandaff Campus, Cardiff CF5 2YB, UK
Three ways to engage.
ICCARP welcomes correspondence from clinicians, scientists, regulators, and partner institutions. Each route below opens a direct, addressed email.